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    <title>Pathophilia</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/" />
    <link rel="self" type="application/atom+xml" href="http://bmartinmd.com/atom.xml" />
    <id>tag:bmartinmd.com,2007-10-12://1</id>
    <updated>2010-02-08T19:21:17Z</updated>
    <subtitle>For the love of disease.</subtitle>
    <generator uri="http://www.sixapart.com/movabletype/">Movable Type Publishing Platform 4.01</generator>

<entry>
    <title>Litigation-Driven Research: Getting Over the Ick Factor</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/02/litigation-driven-research.html" />
    <id>tag:bmartinmd.com,2010://1.764</id>

    <published>2010-02-08T16:15:26Z</published>
    <updated>2010-02-08T19:21:17Z</updated>

    <summary><![CDATA[ Recently I wrote that "plaintiff-sponsored research is disturbing and represents a potentially significant conflict of interest for the&nbsp;investigator who accepts plaintiff funds to perform related studies—particularly studies that may be used to the advantage of the plaintiff in ongoing...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Legal" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="ethics" label="ethics" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="pharma" label="pharma" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ Recently I wrote that "plaintiff-sponsored research is disturbing and represents a potentially significant conflict of interest for the&nbsp;investigator who accepts plaintiff funds to perform related studies—particularly studies that may be used to the advantage of the plaintiff in ongoing...]]>
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #103</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/02/kickback-friday-103.html" />
    <id>tag:bmartinmd.com,2010://1.763</id>

    <published>2010-02-05T23:16:43Z</published>
    <updated>2010-02-05T23:35:09Z</updated>

    <summary> I Soliti Ignoti (1958), aka Persons Unknown or Big Deal on Madonna Street: If this farcical heist movie doesn&apos;t make you shrug, wave your hands, and argue in gibberish Italian with the nearest person, I don&apos;t know what will....</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
         I Soliti Ignoti (1958), aka Persons Unknown or Big Deal on Madonna Street: If this farcical heist movie doesn&apos;t make you shrug, wave your hands, and argue in gibberish Italian with the nearest person, I don&apos;t know what will....
        
    </content>
</entry>

<entry>
    <title>Accutane-PET Study Discredited in Court Opinion</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/02/accutane-pet-study-discredited.html" />
    <id>tag:bmartinmd.com,2010://1.762</id>

    <published>2010-02-05T17:17:30Z</published>
    <updated>2010-02-08T06:08:05Z</updated>

    <summary><![CDATA[ It's one thing for a physician to serve as a medical expert for plaintiffs in court&nbsp;cases. It's very much another when plaintiffs actually commission a physician to conduct a study—the results of which are intended to support their litigation....]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neuropsychiatry" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="accutane" label="Accutane" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="ethics" label="ethics" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ It's one thing for a physician to serve as a medical expert for plaintiffs in court&nbsp;cases. It's very much another when plaintiffs actually commission a physician to conduct a study—the results of which are intended to support their litigation....]]>
        
    </content>
</entry>

<entry>
    <title>fMRI Study Clouds Definition of Vegetative State</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/02/fmri-study-clouds-vs-definition.html" />
    <id>tag:bmartinmd.com,2010://1.761</id>

    <published>2010-02-04T16:49:50Z</published>
    <updated>2010-02-07T07:45:48Z</updated>

    <summary><![CDATA[ Raising a host of questions, from practical to philosophical, English and Belgian investigators showed that some patients with profound disorders of consciousness&nbsp;may be able to&nbsp;communicate—albeit in rudimentary fashion and with the aid of a million-dollar machine. Their functional MRI...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neuropsychiatry" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Trauma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="braininjury" label="brain injury" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="fmri" label="fMRI" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ Raising a host of questions, from practical to philosophical, English and Belgian investigators showed that some patients with profound disorders of consciousness&nbsp;may be able to&nbsp;communicate—albeit in rudimentary fashion and with the aid of a million-dollar machine. Their functional MRI...]]>
        
    </content>
</entry>

<entry>
    <title>The Lancet Tries to Unring a Bell</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/02/lancet-unrings-bell.html" />
    <id>tag:bmartinmd.com,2010://1.760</id>

    <published>2010-02-03T17:03:40Z</published>
    <updated>2010-02-03T18:34:20Z</updated>

    <summary><![CDATA[ That rang 12 years ago. Yesterday, editors of The Lancet&nbsp;officially retracted publication of a 12-year-old debunked study that linked the MMR vaccine&nbsp;to autism, according to the journal's web site, numerous news sources, and countless blogs. The study is believed...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Infectious diseases" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pediatrics" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="autism" label="autism" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="vaccination" label="vaccination" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ That rang 12 years ago. Yesterday, editors of The Lancet&nbsp;officially retracted publication of a 12-year-old debunked study that linked the MMR vaccine&nbsp;to autism, according to the journal's web site, numerous news sources, and countless blogs. The study is believed...]]>
        
    </content>
</entry>

<entry>
    <title>Physician Eyewitness in Haiti</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/02/physician-eyewitness-in-haiti.html" />
    <id>tag:bmartinmd.com,2010://1.759</id>

    <published>2010-02-02T16:06:13Z</published>
    <updated>2010-02-02T17:41:24Z</updated>

    <summary><![CDATA[ A London pediatrician's diary&nbsp;shows that Haiti desperately needs, more than surgeons,&nbsp;supplies and coordination. Writing for the Evening Standard, Dr. Nathaniel Segaren of the Caris Foundation, logs&nbsp;his week of guilt, frustration, appall, effort, and anguish among the mayhem. He concludes,&nbsp;"I...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Health care" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Media" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pediatrics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Trauma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="haiti" label="Haiti" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ A London pediatrician's diary&nbsp;shows that Haiti desperately needs, more than surgeons,&nbsp;supplies and coordination. Writing for the Evening Standard, Dr. Nathaniel Segaren of the Caris Foundation, logs&nbsp;his week of guilt, frustration, appall, effort, and anguish among the mayhem. He concludes,&nbsp;"I...]]>
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #102</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/kickback-friday-102.html" />
    <id>tag:bmartinmd.com,2010://1.758</id>

    <published>2010-01-29T23:17:06Z</published>
    <updated>2010-01-29T23:59:27Z</updated>

    <summary><![CDATA[ The Conversation (1974): Come on. It's been how many years since you've seen this movie?&nbsp;Rediscover what a national treasure Gene Hackman is. It's also one of Coppola's best, and I'm including The Godfather and The Godfather: Part II. For...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ The Conversation (1974): Come on. It's been how many years since you've seen this movie?&nbsp;Rediscover what a national treasure Gene Hackman is. It's also one of Coppola's best, and I'm including The Godfather and The Godfather: Part II. For...]]>
        
    </content>
</entry>

<entry>
    <title>Bill and Melinda Throw Another $10 Billion at Vaccine Development</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/bill-and-melinda-throw-10-billion.html" />
    <id>tag:bmartinmd.com,2010://1.757</id>

    <published>2010-01-29T16:50:36Z</published>
    <updated>2010-01-29T18:02:37Z</updated>

    <summary> In an apparent effort to atone for every Microsoft error message, the Gateses are committing $10 billion USD over the next 10 years for the research, development, and delivery of mortality-reducing vaccines to &quot;the world&apos;s poorest countries.&quot; Some details...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Infectious diseases" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pediatrics" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="philanthropy" label="philanthropy" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="vaccination" label="vaccination" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
         In an apparent effort to atone for every Microsoft error message, the Gateses are committing $10 billion USD over the next 10 years for the research, development, and delivery of mortality-reducing vaccines to &quot;the world&apos;s poorest countries.&quot; Some details...
        
    </content>
</entry>

<entry>
    <title>Plaintiffs: Allergan Promoted Off-Label Use of Botox</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/allergans-alleged-off-label-promotion.html" />
    <id>tag:bmartinmd.com,2010://1.756</id>

    <published>2010-01-28T16:39:00Z</published>
    <updated>2010-02-07T17:07:47Z</updated>

    <summary><![CDATA[ In Orange County, California, opening statements began yesterday&nbsp;in a multi-plaintiff civil case against Allergan, maker of Botox. The plaintiffs, including the mother of a deceased 7-year-old Texas girl with cerebral palsy, argue that off-label use of the company's drug...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="FDA" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Marketing" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="botulinumtoxin" label="botulinum toxin" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ In Orange County, California, opening statements began yesterday&nbsp;in a multi-plaintiff civil case against Allergan, maker of Botox. The plaintiffs, including the mother of a deceased 7-year-old Texas girl with cerebral palsy, argue that off-label use of the company's drug...]]>
        
    </content>
</entry>

<entry>
    <title>Huh? When? Novartis Submitted NDA for Fingolimod in December</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/novartis-submitted-fingolimod-nda.html" />
    <id>tag:bmartinmd.com,2010://1.755</id>

    <published>2010-01-27T16:24:09Z</published>
    <updated>2010-01-29T08:05:45Z</updated>

    <summary><![CDATA[ While plowing through Novartis's newly released financial report for 2009, I found this quiet gem: the&nbsp;"dossier" for Gilenia, the proposed trade name for fingolimod or FTY720, was submitted to the FDA and the&nbsp;European Medicines Agency&nbsp;in December.&nbsp;Now by "dossier," I...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="FDA" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="fda" label="FDA" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="multiplesclerosis" label="multiple sclerosis" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="pharma" label="pharma" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ While plowing through Novartis's newly released financial report for 2009, I found this quiet gem: the&nbsp;"dossier" for Gilenia, the proposed trade name for fingolimod or FTY720, was submitted to the FDA and the&nbsp;European Medicines Agency&nbsp;in December.&nbsp;Now by "dossier," I...]]>
        
    </content>
</entry>

<entry>
    <title>Guidelines Recommend Botox for Pediatric Spasticity</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/botox-for-spasticity.html" />
    <id>tag:bmartinmd.com,2010://1.754</id>

    <published>2010-01-26T17:04:59Z</published>
    <updated>2010-02-01T16:43:15Z</updated>

    <summary><![CDATA[While the FDA and Allergan remain at an impasse&nbsp;on how to disseminate off-label safety information&nbsp;for Botox, the American Academy of Neurology (AAN)&nbsp;just published its recommendations&nbsp;for&nbsp;use of&nbsp;the&nbsp;toxin in children with spasticity due to cerebral palsy (CP).* On the basis of&nbsp;14 20...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="FDA" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pediatrics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="botulinumtoxin" label="botulinum toxin" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[While the FDA and Allergan remain at an impasse&nbsp;on how to disseminate off-label safety information&nbsp;for Botox, the American Academy of Neurology (AAN)&nbsp;just published its recommendations&nbsp;for&nbsp;use of&nbsp;the&nbsp;toxin in children with spasticity due to cerebral palsy (CP).* On the basis of&nbsp;14 20...]]>
        
    </content>
</entry>

<entry>
    <title>Brief Primer: Speakers&apos; Bureaus vs Continuing Medical Education (CME) Programs</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/speakers-bureaus-vs-cme.html" />
    <id>tag:bmartinmd.com,2010://1.753</id>

    <published>2010-01-25T16:10:53Z</published>
    <updated>2010-01-25T18:18:51Z</updated>

    <summary><![CDATA[ Once again:&nbsp;I'll attempt&nbsp;to clarify the difference between participating in speakers' bureaus and delivering continuing medical education (CME). The repeat&nbsp;effort to distinguish the two is prompted by today's&nbsp;newspaper and blog reports of physician Lawrence DuBuske, who&nbsp;decided to give&nbsp;up his academic...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="CME" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Medical education" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="cme" label="CME" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="medicaleducation" label="medical education" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ Once again:&nbsp;I'll attempt&nbsp;to clarify the difference between participating in speakers' bureaus and delivering continuing medical education (CME). The repeat&nbsp;effort to distinguish the two is prompted by today's&nbsp;newspaper and blog reports of physician Lawrence DuBuske, who&nbsp;decided to give&nbsp;up his academic...]]>
        
    </content>
</entry>

<entry>
    <title>&quot;Walking Drug&quot; Approved for All MS Patients</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/ms-walking-drug-approved.html" />
    <id>tag:bmartinmd.com,2010://1.752</id>

    <published>2010-01-24T16:13:48Z</published>
    <updated>2010-01-27T05:34:13Z</updated>

    <summary><![CDATA[ Friday&nbsp;the FDA announced its approval of dalfampridine* (Ampyra; Acorda/Elan) to improve walking in all patients with multiple sclerosis. The drug, in the form of a sustained-release&nbsp;10-mg tablet,&nbsp;has been assessed in at least 4 well-controlled MS trials; but a non-sustained-release...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="multiplesclerosis" label="multiple sclerosis" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ Friday&nbsp;the FDA announced its approval of dalfampridine* (Ampyra; Acorda/Elan) to improve walking in all patients with multiple sclerosis. The drug, in the form of a sustained-release&nbsp;10-mg tablet,&nbsp;has been assessed in at least 4 well-controlled MS trials; but a non-sustained-release...]]>
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #101</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/kickback-friday-101.html" />
    <id>tag:bmartinmd.com,2010://1.751</id>

    <published>2010-01-22T20:53:56Z</published>
    <updated>2010-01-22T21:28:22Z</updated>

    <summary><![CDATA[ Pickup on South Street (1953): Cops trailing a va-voom courier of&nbsp;government microfilm (Jean Peters)&nbsp;are diverted to a subway pickpocket (Richard Widmark), who unknowingly steals it. The pickpocket then has to contend with prying visits from the courier, the cops,...]]></summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        <![CDATA[ Pickup on South Street (1953): Cops trailing a va-voom courier of&nbsp;government microfilm (Jean Peters)&nbsp;are diverted to a subway pickpocket (Richard Widmark), who unknowingly steals it. The pickpocket then has to contend with prying visits from the courier, the cops,...]]>
        
    </content>
</entry>

<entry>
    <title>&quot;Extraordinary Measures&quot;: Not Even Good Enough for Premium Movie Channels</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2010/01/extraordinary-measures-reviews.html" />
    <id>tag:bmartinmd.com,2010://1.750</id>

    <published>2010-01-22T17:01:43Z</published>
    <updated>2010-01-23T19:38:03Z</updated>

    <summary> The latest in potentially cloying medical movies, which I avoid like they&apos;re pandemic H1N1, is the newly released Extraordinary Measures, starring the dramatically limited Harrison Ford* and the doughy, but generally likeable, Brendan Fraser. The story, at least on...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Media" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
         The latest in potentially cloying medical movies, which I avoid like they&apos;re pandemic H1N1, is the newly released Extraordinary Measures, starring the dramatically limited Harrison Ford* and the doughy, but generally likeable, Brendan Fraser. The story, at least on...
        
    </content>
</entry>

</feed>

