Pathophilia tag:bmartinmd.com,2007-10-12://1 2012-05-16T14:45:32Z For the love of disease. Movable Type Publishing Platform 4.01 Novel Anti-Amyloid MAb to Be Studied in Familial Alzheimer's tag:bmartinmd.com,2012://1.1215 2012-05-16T13:53:45Z 2012-05-16T14:45:32Z A remarkable, unprecedented development. Roche's anti-amyloid MAb, crenezumab (for which there are no entries at PubMed—!), will be given in an attempt to stave off familial Alzheimer disease. According to Reuters and the NYT, the experimental drug will be studied... bmartin http://www.pathophilia.com A remarkable, unprecedented development. Roche's anti-amyloid MAb, crenezumab (for which there are no entries at PubMed—!), will be given in an attempt to stave off familial Alzheimer disease. According to Reuters and the NYT, the experimental drug will be studied... FDA Extends Cardiovascular Monitoring for Gilenya tag:bmartinmd.com,2012://1.1214 2012-05-15T12:52:01Z 2012-05-15T13:25:07Z The FDA has revised its recommendations for cardiovascular monitoring after the initiation of Gilenya (fingolimod), Novartis's oral drug for relapsing-remitting MS. The new recommendations, which extend the post-dosage monitoring for bradycardia from 6 to 24 hours, are based on the... bmartin http://www.pathophilia.com The FDA has revised its recommendations for cardiovascular monitoring after the initiation of Gilenya (fingolimod), Novartis's oral drug for relapsing-remitting MS. The new recommendations, which extend the post-dosage monitoring for bradycardia from 6 to 24 hours, are based on the... FDA Warns of Risks With "Liberation Procedure" tag:bmartinmd.com,2012://1.1212 2012-05-10T14:58:26Z 2012-05-10T15:17:00Z This morning, the FDA has finally stepped in and is warning healthcare professionals and MS patients alike about death and other injuries associated with the so-called "liberation procedure" (ugh), which amounts to either angioplasty or stenting of (typically) jugular veins.... bmartin http://www.pathophilia.com This morning, the FDA has finally stepped in and is warning healthcare professionals and MS patients alike about death and other injuries associated with the so-called "liberation procedure" (ugh), which amounts to either angioplasty or stenting of (typically) jugular veins.... Results of Phase 3 MAb Trials in Alzheimer Disease Are Hotly Anticipated tag:bmartinmd.com,2012://1.1210 2012-05-03T15:14:45Z 2012-05-03T15:48:12Z For the Internet's edification, the phase 3 trials of MAbs in AD are tabulated by drug (bapineuzumab, solanezumab) and expected completion date. Although the phase 3 trial of bapineuzumab in APOE Normal 0 false false false EN-US X-NONE X-NONE /*... bmartin http://www.pathophilia.com For the Internet's edification, the phase 3 trials of MAbs in AD are tabulated by drug (bapineuzumab, solanezumab) and expected completion date. Although the phase 3 trial of bapineuzumab in APOE Normal 0 false false false EN-US X-NONE X-NONE /*... Venous Insufficiency in MS: Two More Studies Fail to Replicate Zamboni Data tag:bmartinmd.com,2012://1.1209 2012-05-02T14:10:24Z 2012-05-02T15:05:09Z Chronic cerebrospinal venous insufficiency (CCSVI) is neither common, nor more common, in patients with multiple sclerosis, say investigators at the University of Texas Health Sciences Center in Houston. According to 2 preliminary reports presented at the recent annual meeting of... bmartin http://www.pathophilia.com Chronic cerebrospinal venous insufficiency (CCSVI) is neither common, nor more common, in patients with multiple sclerosis, say investigators at the University of Texas Health Sciences Center in Houston. According to 2 preliminary reports presented at the recent annual meeting of... Kick-Back Friday: #198 tag:bmartinmd.com,2012://1.1207 2012-04-27T22:59:50Z 2012-04-27T23:28:31Z Small Town Murder Songs (2010): A heavy and heavily mustachioed Peter Stormare (the kidnapping guy from Fargo) plays Walter, a born-again cop who investigates the local murder of a stripper in his rural Canadian town. However, director Ed Gass-Donnelly places... bmartin http://www.pathophilia.com Small Town Murder Songs (2010): A heavy and heavily mustachioed Peter Stormare (the kidnapping guy from Fargo) plays Walter, a born-again cop who investigates the local murder of a stripper in his rural Canadian town. However, director Ed Gass-Donnelly places... Many Physicians Regret Career Choice tag:bmartinmd.com,2012://1.1206 2012-04-27T13:03:13Z 2012-04-27T13:25:31Z bmartin http://www.pathophilia.com Predicting the Supremes' Decision on the Affordable Care Act tag:bmartinmd.com,2012://1.1204 2012-04-19T14:51:20Z 2012-04-19T15:47:40Z Law professor Mark Hall (Wake Forest) makes predictions in the latest NEJM about the Supreme Court's decision on the recently argued Affordable Care Act (ACA)—specifically with respect to the constitutionality of the individual insurance mandate. (Although frankly, anyone who's been... bmartin http://www.pathophilia.com Law professor Mark Hall (Wake Forest) makes predictions in the latest NEJM about the Supreme Court's decision on the recently argued Affordable Care Act (ACA)—specifically with respect to the constitutionality of the individual insurance mandate. (Although frankly, anyone who's been... A Non-Rhetorical Question: What's the Accuracy of a Clinical Diagnosis of Alzheimer Disease? tag:bmartinmd.com,2012://1.1202 2012-04-10T13:56:04Z 2012-04-11T03:16:43Z The use of Avid/Lilly's newly approved amyloid tracer, Amyvid, hinges on the accuracy (or inaccuracy) of a clinical diagnosis of Alzheimer disease (AD) during life. If the historic accuracy of a clinical diagnosis of AD is generally high—meaning the correlation... bmartin http://www.pathophilia.com The use of Avid/Lilly's newly approved amyloid tracer, Amyvid, hinges on the accuracy (or inaccuracy) of a clinical diagnosis of Alzheimer disease (AD) during life. If the historic accuracy of a clinical diagnosis of AD is generally high—meaning the correlation... What if the FDA Approved an Imaging Agent, and Nobody Used It? tag:bmartinmd.com,2012://1.1201 2012-04-09T14:49:04Z 2012-04-09T16:14:42Z Much to my disquiet, the FDA approved Amyvid (florbetapir), an amyloid imaging agent, late last Friday. The radiolabeled tag for amyloid-beta, which is intended to be used with PET scanning, latches onto the stuff of neuritic plaques in the brains... bmartin http://www.pathophilia.com Much to my disquiet, the FDA approved Amyvid (florbetapir), an amyloid imaging agent, late last Friday. The radiolabeled tag for amyloid-beta, which is intended to be used with PET scanning, latches onto the stuff of neuritic plaques in the brains... WSJ Traces "Murky Path" of Fake Avastin tag:bmartinmd.com,2012://1.1200 2012-04-05T14:43:14Z 2012-04-05T15:44:40Z And at least one questionable wholesaler, Thomas Houghton through his UK-based River East Supplies, appears to be involved in both the February and most recent transactions.The WSJ traces the route of fake Avastin that cropped up in the United States... bmartin http://www.pathophilia.com And at least one questionable wholesaler, Thomas Houghton through his UK-based River East Supplies, appears to be involved in both the February and most recent transactions.The WSJ traces the route of fake Avastin that cropped up in the United States... More Counterfeit Avastin (Altuzan) Pops Up in the US Market tag:bmartinmd.com,2012://1.1199 2012-04-04T15:23:40Z 2012-04-04T16:02:49Z From the FDA. The facts (ma'am):A counterfeit version of bevacizumab, disguised as Roche's Altuzan—a brand that is approved in Turkey but not the United States—was recently discovered.The product "contained no active ingredient," although the agency didn't reveal what it did... bmartin http://www.pathophilia.com From the FDA. The facts (ma'am):A counterfeit version of bevacizumab, disguised as Roche's Altuzan—a brand that is approved in Turkey but not the United States—was recently discovered.The product "contained no active ingredient," although the agency didn't reveal what it did... Anti-Amyloid MAb May Affect Tau in Alzheimer Disease tag:bmartinmd.com,2012://1.1198 2012-04-03T13:17:12Z 2012-04-03T15:28:22Z With an emphasis on "may." Newly published post-hoc data from bapineuzumab's phase 2 studies indicate that the anti-amyloid MAb reduces CSF levels of tau—a traditional downstream marker of neurodegeneration in AD (as well as in similar diseases). These data appear... bmartin http://www.pathophilia.com With an emphasis on "may." Newly published post-hoc data from bapineuzumab's phase 2 studies indicate that the anti-amyloid MAb reduces CSF levels of tau—a traditional downstream marker of neurodegeneration in AD (as well as in similar diseases). These data appear... WTF: The Runup on Elan Continues tag:bmartinmd.com,2012://1.1197 2012-04-02T14:20:25Z 2012-04-02T15:12:41Z Presumably powered on expectations about bapineuzumab and its phase 3 results—which are expected to be released later this year (possibly at the AAIC in mid-July). But see Adam Fuerstein's article of March 19th for an appropriate, cautionary reminder.Bapineuzumab, an anti-amyloid... bmartin http://www.pathophilia.com Presumably powered on expectations about bapineuzumab and its phase 3 results—which are expected to be released later this year (possibly at the AAIC in mid-July). But see Adam Fuerstein's article of March 19th for an appropriate, cautionary reminder.Bapineuzumab, an anti-amyloid... Kick-Back Friday: #197 tag:bmartinmd.com,2012://1.1196 2012-03-31T01:24:49Z 2012-03-31T01:51:28Z The Guard (2011): John Michael McDonough, brother of Martin, directs the outstanding Irish character actor Brendan Gleeson in a wry, self-aware homage to the provincial Irish cop, or Garda. Gleeson is a highly unconventional officer who partners up with a... bmartin http://www.pathophilia.com The Guard (2011): John Michael McDonough, brother of Martin, directs the outstanding Irish character actor Brendan Gleeson in a wry, self-aware homage to the provincial Irish cop, or Garda. Gleeson is a highly unconventional officer who partners up with a...