Genetics: May 2008 Archives
Here's a post that will increase my spam count:
Canadian investigators found that sildenafil (Viagra; Pfizer) maintained contractile function of the heart in a mouse model (mdx) of Duchenne muscular dystrophy. The results of the study, which was not supported by Pfizer, were published in the latest issue of PNAS and picked up in wincingly cute fashion by Forbes ("New Use Pops up for Viagra"). Sildenafil, a selective inhibitor of cGMP-specific phosphodiesterase 5, was assessed in the mdx model, because the investigators found that DMD's late cardiomyopathy may be preceded by defective formation of cGMP.
Image: iStockPhoto.
